Functional and preventive biology

 
 

Functional and preventive biology allow the evaluation of the unique biochemical characteristics of each individual and, as a consequence, the drafting of a personalised programme to restore physiological, psychological, and structural equilibrium.

This approach can be taken with healthy patients, even those with no risk factors, to correct alterations (deficits or excesses) on a biochemical level.

These changes are quite frequent because modern diets are absolutely inadequate for our enzyme system, resulting in micronutrient deficits (vitamins, minerals, fatty acids…) that are very common and triggering cell dysfunction and fragility.

Many diseases (probably all of them) develop silently during periods that vary between 3 and 15 years or more. Preventive biology enables the establishment of an effective strategy to prevent their onset.

It can also be used for patients with known medical risk factors or specific diseases to target these problems at their origins and limit the effects of the pathologies, delaying their evolution and preventing the development of other illnesses

The best known preventive biology tests are:

Fatty acids profile

Fatty acids, together with cholesterol, the main constituents of fats or lipids.

In addition to their major role as a source of energy and cell membrane constituents, fatty acids have metabolic functions that vary according to their nature. Some of them are precursors of molecules that regulate important physiological functions, such as:

platelet aggregation, inflammation, vascular tone, hydro-electrolytic balance, immunity…others can regulate gene expression for lipid metabolism.

Cholesterol is also part of the lipids. It is the precursor of steroid hormones (oestrogens, testosterone, etc.), vitamin D, Q10 Coenzyme, and biliary acids. It is also an important element of cell membranes, especially in the brain.

It has been demonstrated that quantitative and qualitative anomalies of fatty acids are associated with numerous inflammatory pathologies (cardio-vascular diseases, neuro-degenerative diseases, auto-immune diseases, allergies, obesity, diabetes, depression, and mood swings), as well as cancers.

The qualitative and quantitative distribution of different types of fatty acids is intrinsically linked to diet and the efficiency of metabolic pathways that assure their transformation.

The profile of fatty acids indicates the quantitative distribution of fatty acids in the circulating phospholipids and is representative of the patient’s food and metabolism over the last three months.

The correction of their deficit or excess is essential for re-establishing the equilibrium of the organism.

Oxidative stress

This is a mechanism linked with inflammatory and auto-immune diseases as well as aging.

The markers of oxidative stress are:

  1. Anti-LDL oxidized anti-bodies: it indicates an oxidation of LDL. This oxidation is considered the triggering element of arteriosclerosis.
  2. Urinary rate of 8-Hydroxyguanosine: the DNA of our cells is constantly attached by free radicals. This often happens at the level of carbon 8 of guanine. This oxidation modifies the DNA and impedes protein synthesis. A repair system removes the undamaged molecule, the 8-OHDG, will then enters the plasma and is eliminated with urine. An increase of urinary 8-OHDG indicates the oxidative damage of DNA and is therefore  a marker of oxidative stress.

It is also possible to evaluate the anti-free radical defence system.

Vitamin, mineral, and trace element dosages

It defines the needs, identifies the dietary deficits, and intestinal absorption.

Neurotransmitter profile

This test quantifies the balance of three types of neurotransmitters (dopaminergic, noradrenergic/adrenergic, serotonin axes).
It is useful when treating mood swings and behavioural problems.

Complete protein profile:

This test indicates humoral immunity, inflammation, and malnutrition.
Proteins play an important role in humoral immunity, artherogenesis, the metabolism of iron and inflammatory pathologies.

Urinary organic metabolites

The bacteria of the digestive system rejects catabolic products, which are reabsorbed and then eliminated by the kidneys. In the case of dysbiosis (alteration of intestinal flora), the type of metabolites excreted is changed. The increased rates of the different metabolites enables the diagnosis of mycosis or bacterial dysbiosis. This allows a targeted therapeutic approach. This test also evaluates the restoration of a normal intestinal flora.

Fecalogram

This is the complete functional exploration of digestion, enabling the identification of  problems in transit, problems in different stages of digestion, indigestion, problems in intestinal absorption, and the lesions of the digestive tract.

Food intolerances

A test aimed at highlighting problems concerning digestive tolerance, anomalies in intestinal permeability according to a panel of food antigens.

Lymphocyte typing

This test enables to have an overview of the different types of lymphocytes and evaluate the individual's global defence system.